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Clinical Trials

Understanding Clinical Trials

Clinical trials are strictly controlled human studies of new and emerging therapies. At Hospital for Special Surgery, these trials incorporate state-of-the-art patient care, while carefully evaluating how best to apply the most recent innovations in orthopedics and rheumatology.

The safety of study participants is our top priority. Clinical trials at Hospital for Special Surgery must first be approved by an Institutional Review Board (IRB), which includes doctors, administrators, ethicists, and members of the general public. The IRB provides continuing surveillance of the trial as well as periodic review of study results. Before a treatment can be tested in people, it must be shown to be safe and effective in laboratory and animal studies. Volunteers are fully informed of possible risks and sign a consent form before being accepted into a clinical trial.

The safety and effectiveness of clinical trials are reviewed by the U.S. Food and Drug Administration. That agency determines if and when a clinical trial provides evidence that the treatment under study offers improvements in care that can be made available to all patients with a particular condition.

Know Your Rights

Before enrolling in a clinical trial, you will undergo the informed consent process. At this time, the investigator will explain the purpose of the trial, its expected benefits, any possible risks or side effects, and what your role will be. This is the time to ask questions! If you want to join the trial, you must sign the informed consent documents. You can leave a clinical trial at any time without penalty.

Learn more about the critical role of the HSS Institutional Review Board in protecting people who volunteer to participate in clinical trials.

ClinicalTrials.gov

ClinicalTrials.gov provides regularly updated information about federally and privately supported clinical research in human volunteers. ClinicalTrials.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details.


Clinical Trials at HSS

View Clinical Trials by Condition

IRB# Clinical Trial Principal Investigator
28019 Early Mobilization following Adult Acquired Flatfoot Deformity Reconstruction Jonathan T. Deland, M.D.
Next Generation Baby Shoe – Medical Pilot Study 28068
28027 A Phase 1b Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation study with an open-label extension to evaluate the safety and tolerability of multiple IV doses of Medi-545, a fully Human Anti-interferon-alpha Monoclonal Antibody, in patients with Systemic Lupus Erythematosus Kyriakos A. Kirou, MD
28041 The Effect of Ischemic Preconditioning on Systemic Inflammatory Markers after Total Knee Arthroplasty Stavros G. Memtsoudis, MD
28021 In Vivo Radiographic Validation of Novel EMED Plantar Pressure Masking Algorithm Jonathan T. Deland, MD
22122 PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Jane E. Salmon, MD
21137 Minimally Invasive Surgical Approach versus Standard Total Knee Arthroplasty: A Prospective Randomized Double Blinded Study Comparing Postoperative Strength Bryan J. Nestor. MD
27142 A Randomized Comparison of NeoCart® to Microfracture for the Repair of Articular Cartilage Injuries in the Knee Riley J. Williams III, MD
28023 Cognitive Dysfunction, Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging (MRI) in Antiphospholipid Antibody (aPL)-negative Systemic Lupus Erythematosus (SLE) versus aPL-positive non-SLE Patients Doruk Erkan, MD
26079 Deep Vein Thrombosis (DVT) Prevention in Total Hip Replacement: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH) Douglas E. Padgett, MD
27058 A Phase I, Randomized, Double-blind, Placebo-controlled, Escalating Single- and Multiple-dose Study of the Safety, Tolerability, and Pharmakokinetics of RhuMab IFN alpha in Adults with Systemic Lupus Erythematosus Kyriakos A. Kirou, MD
28028 Results of EndoButton Fixation Technique for Distal Biceps Tendon Repair Scott W. Wolfe, MD
27135 The Systemic Lupus Erythematosus (SLE) Activity Gene Expression (SAGE) Study Kyriakos A. Kirou, MD
27127 Prospective Study of the effects of Femoral Nerve Block on Quadriceps Strength Post ACL Allograft Reconstruction Thomas L. Wickiewicz, MD
28005 Effects of Fluvastatin on Proinflammatory and Prothrombotic markers in Antiphospholipid Syndrome Doruk Erkan, MD
27128 Pilot Study Assessing Weight Bearing Multiplanar Imaging Compared to Supine CT and Upright Conventional Imaging of the Knee Andrew Pearle, MD
27076 A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled 76 Week Study to Evaluate the Efficacy and Safety of Belimumab (GHS1006, LymphoStat-B), A fully Human monoclonal Anti-BlyS Antibody, in Subjects with Systemic Lupus Erythematosus (SLE). Michael D. Lockshin, M.D.
27122 Supraclavicular vs Interscalene Brachial Plexus Block for Shoulder Surgery Christopher A DiMeo, MD
27089 A Sequential Adaptive Phase II/III Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Abatacept Versus Placebo on a Background of Mycophenolate Mofetil and Glucocorticosteroids in Subjects with Active Proliferative Glomerulonephritis Due to Systemic Lupus Erythematosus(SLE) Kyriakos A. Kirou, MD, FACR
26043 A Study of Hyaluronan (Synvisc) for the Treatment of Osteoarthritis in the Thumb: Randomized Control Trial Lisa A. Mandl, MD, MPH
23034 Open Label Trial for Treating Carpometacarpal Osteoarthritis: PILOT STUDY - Sub-study on Normal Controls Lisa A. Mandl, MD, MPH
26131 Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Hip Arthroplasty Cohort Thomas P. Sculco, MD
26117 Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Shoulder Arthroplasty Cohort Robert Marx MD, MSc
26132 Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Knee Arthroplasty Cohort Thomas P. Sculco, MD
26002 Scleroderma Cyclophosphamide or Transplantation (SCOT) Study Robert F. Spiera, MD
27049 Gleevec in the Treatment of Systemic Sclerosis Robert F. Spiera, MD
27071 Adhesive Capsulitis: A Quantitative Analysis of Myofibroblast Proliferation Jo A Hannafin, MD
27081 A Prospective, Randomized, Controlled, Multi-Center, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of GEM OSI Compared to Autologous Bone Graft as a Bone Regeneration Device in Foot and Ankle Fusions Andrew J. Elliott, MD
27050 The Effect of McConnell Shoulder Taping on EMG Activity and Torque Production of the Shoulder Muscles in Subjects With Anterior Shoulder Instability. Sherry I. Backus PT, DPT, MA
27020 Intraarticular Corticosteroid Injection for Idiopathic Adhesive Capsulitis of the Shoulder Jennifer L. Solomon, MD
27022 RITAPS: A Pilot Study Of Rituximab For The Anticoagulation-Resistant Manifestations Of Antiphospholipid Syndrome (APS) Doruk Erkan, MD
27041 Fragile Bone Registry Joseph M. Lane, MD
27012 Efficacy and Side Effect Profile of Ultrasound-guided Supraclavicular Block for Shoulder Surgery Christopher A DiMeo, MD
27027 Vitamin D Status Among Trauma Patients; Acute Fractures/Non-unions vs. Primary Joint Arthroplasty (control population) Joseph M. Lane, MD
27016 Osteogenic Differentiation of Human Mesenchymal Stem Cells Wei Zhu, Ph.D.
26118 Genetic Mapping Studies of Adolescent Idiopathic Scoliosis Cathleen L. Raggio, MD
26120 Facet Joint Intraarticular Steroid Injections versus Caudal Epidural Steroid Injections to Treat Axial Back Pain in Grade 1-2 Degenerative Spondylolisthesis Paul M. Cooke, MD
23108 Evaluation of Intra-articular Injuries as Predictors of Function and Arthritis Robert G. Marx, MD
27003 A Randomized Controlled Trial Evaluating the Efficacy and Complications of Interscalene Block Using the Nerve Stimulator vs. Ultrasound Approach Spencer S. Liu, MD
27001 Incidence and Severity of Nausea after Primary Total Hip Arthroplasty for Osteoarthritis Jacques T. YaDeau, MD, PhD
26114 A Pilot Study to Obtain Initial Information on Gene Expression in the Human Intervetebral Disc: The Origin and Fate of the Nucleus Pulposus Federico P. Girardi, MD
24067 Database of the Gosden Robinson Early Arthritis Center (EAC): Analysis of Types of Patients Recruited to an Urban EAC Lisa C. Vasanth, MD
23081 MINDFULL: A Randomized, Controlled Pilot Study of a Cognitive Rehabilitation Intervention Program in Systemic Lupus Erythematosus Patients Melanie J. Harrison, MD, MS
26073 Evaluation of migration of a cementless, flat, tapered femoral component using RSA Edwin P. Su, MD
25039 A Randomized Double Blind Placebo Controlled Multi-Center Parallel Group Study of One Year Duration Followed by Two Years of open-label Treatment to Determine the Safety and Efficacy of Orally Administered 2.5 mg or 5.0 mg Daily Risedronate Cathleen L. Raggio, MD
27037 Design, Development, and Consistency of a Hand Held Tibio-Fibular Torsion Device Corinne McCarthy, PT, DPT, MS
23017 CORRONA Data Collection Program Melanie J. Harrison, MD, MS
25058 EXPLORER: A randomized, double-blind, placebo controlled, multicenter, phase II/III study to evaluate the efficacy and safety of rituximab in subjects with moderate to severe systemic lupus erythematosus Michael D. Lockshin, MD
22007 Hyalgan Treatment of Osteoarthritis in Post-Operative Knee Arthroplasty Patients Geoffrey Westrich, MD
22129 Bone Tunnel Widening Following ACL (Anterior Cruciate Ligament) Reconstruction Scott Rodeo, MD
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