Research

Effect of Epinephrine versus Phenylephrine on Transcranial Doppler Cerebral Blood Flow Velocity during Hypotensive Epidural Anesthesia

IRB Number: 10091
(inactive trial)

Institutional Review Board, Hospital for Special Surgery

July 27, 2010

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Principal Investigator

Nigel E. Sharrock, MD, ChB

Co-Investigators

Anna Maria Bombardieri
George Go

Summary

This study will assess the blood flow in the brain under hypotensive epidural anesthesia (HEA) for hip replacement. We aim to conduct a study to investigate if under HEA there is a difference in terms of cerebral blood flow using two different drugs to control blood pressure, called epinephrine and phenylephrine. The infusion of the drug will be randomized (similar to the toss of a coin) so each patient will receive one of the medication.
Cerebral blood flow will be measured with an ultrasound probe of the size of a pencil  that will be placed on the side of patientís head just in front of the ear. The monitor will record the blood flow in a vessel of the brain. A total of 56 patients will be enrolled in the study (28 patients in each group).  The enrollment period will be approximately 1 year. The patient will participate in the study for the duration of the surgery.

Inclusion/Exclusion Criteria

In the study will be included patients undergoing total hip replacement under hypotensive epidural anesthesia. Patients with specific cardiovascular diseases ( stenosis of the aortic valve, stenosis of the carotid artery, with a low heart rate and with cardiac conducting problems) or who take certain class of drugs ( amiodarone, beta-blockers) will be excluded from participating in the study.

 

Contact Information

Nigel Sharrock,MD
sharrockn@hss.edu
212. 606. 1062



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