Severe Lupus Nephritis (LN) with Response to Aggressive Multimodal Management

This case appears in the HSS publication, Grand Rounds from HSS - Management of Complex Cases, Fall 2012 - Volume 3, Issue 3, Case 1

Case 1, presented by Nancy Pan, MD, a recent graduate of our Pediatric Rheumatology Training Program, Kyriakos A. Kirou, MD, and their colleagues, describes a woman with lupus nephritis who developed a dramatic exacerbation of her disease, including lifethreatening hypertension and massive proteinuria. Two renal biopsies, performed during two distinct flares, demonstrated the evolution of changes consistent with chronic damage. Aggressive immunosuppressive and antihypertensive therapy, using multiple agents, resulted in significant clinical improvement.

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