The Mineralized Tissues Laboratory conducts studies on the mechanisms of biologic calcification in health and disease and on the changes that occur in mineralized tissues during development. Research methodologies include cell culture, x-ray diffraction, FTIR spectroscopy, FTIR micro-spectroscopy and imaging, micro-computed tomography, TEM and SEM, along with techniques of cell and molecular biology, image analysis, and solution chemistry.
Current investigations are focusing on the roles of collagen and noncollagenous extracellular matrix proteins in the regulation of bone and tooth mineralization based on solution studies and studies in transgenic animals; the effects of cell and matrix age and composition on in vitro mineral initiation in a model of endochondral ossification, and the changes in the composition of mineral and matrix in osteoporotic and normal bones before and after treatment with anti-resorptive and anabolic agents.
Roy R, Kudryashov V, Binderman I, Boskey AL. The role of apoptosis in mineralizing murine versus avian micromass culture systems. J Cell Biochem. 2010 Oct 15;111(3):653-8.
Hosogane N, Huang Z, Rawlins BA, Liu X, Boachie-Adjei O, Boskey AL, Zhu W. Stromal derived factor-1 regulates bone morphogenetic protein 2-induced osteogenic differentiation of primary mesenchymal stem cells. Int J Biochem Cell Biol. 2010 Jul;42(7):1132-41.
Gericke A, Qin C, Sun Y, Redfern R, Redfern D, Fujimoto Y, Taleb H, Butler WT, Boskey AL. Different forms of DMP1 play distinct roles in mineralization. J Dent Res. 2010 Apr;89(4):355-9.
Gourion-Arsiquaud S, Faibish D, Myers E, Spevak L, Compston J, Hodsman A,Shane E, Recker RR, Boskey ER, Boskey AL. Use of FTIR spectroscopic imaging to identify parameters associated with fragility fracture. J Bone Miner Res. 2009 Sep;24(9):1565-71
Adele Boskey, PhD