Musculoskeletal Integrity Program

Eve Donnelly, PhD

Research Description

Dr. Donnelly studies the effects of tissue mineral and matrix properties on the material and structural behavior of bone. Her research at HSS focuses on characterizing disease- and treatment-induced changes in the properties of mineral and collagen and relating these changes in bone tissue composition to fracture risk. Techniques include Fourier transform infrared imaging, x-ray diffraction, multiphoton microscopy, atomic force microscopy, and nanoindentation. The clinical relevance of this work lies in its potential to improve pharmacologic treatment for osteoporosis to enhance bone quality and minimize fracture risk

Selected Awards

  • National Research Service Award, NIH/NIAMS, 2008-2011
  • New Investigator Recognition Award, 55th Annual Meeting of the Orthopaedic Research Society, 2009
  • Alice L. Jee Memorial Young Investigator Award, Sun Valley Workshop on Skeletal Tissue Biology, 2007
  • Selected Professions Dissertation Fellowship, American Association of University Women Educational Foundation, 2005-2006
  • Young Investigator Award, NIAMS-ASBMR Meeting, Bone Quality: What Is It and Can We Measure It? 2005
  • Best Student/Young Investigator, Biological and Bio-Inspired Materials and Devices Symposium, Materials Research Society Spring Meeting, 2004
  • Cornell University Graduate Fellowship, 2001

Education

PhD, Mechanical Engineering, Cornell University, 2007
MS, Materials Science and Engineering, Stanford University, 2001
BS, Materials Science and Engineering, Stanford University, 2000

Appointments

Postdoctoral Fellow, Mineralized Tissues Laboratory, Hospital for Special Surgery

Publications

  • Unnanuntana A, Gladnick B, Donnelly E, and Lane JM. Assessment of fracture risk. J Bone Joint Surg Am, in press.
  • Farnum CE, Williams RW, and Donnelly E. Multiphoton imaging of primary cilia in skeletal tissues. Method Cell Biol, in press.
  • Donnelly E, Ascenzi M-G, and Farnum CE. (2009) Primary cilia are highly oriented with respect to collagen direction and long axis of extensor tendon. J Orthop Res, in press, published online 7/14/09, DOI 10.1002/jor.20946.
  • Donnelly E, Boskey AL, Baker SP, and van der Meulen MCH. (2009) Effects of tissue age on bone tissue material composition and nanomechanical properties in the rat cortex. J Biomed Mater Res, in press, published online 3/19/08, DOI 10.1002/jbm.a.32442 .
  • Donnelly E, Williams RW, and Farnum CE. (2008) The primary cilium of connective tissue cells: Imaging by multiphoton microscopy. Anat Rec 291: 1062-1073.
  • Donnelly E, Williams RW, Downs SA, Dickinson ME, Baker SP, and van der Meulen MCH. (2006) Quasistatic and dynamic nanomechanical properties of cancellous bone tissue relate to collagen content and organization. J Mater Res 21: 2106-2117.
  • Donnelly E, Baker SP, Boskey AL, and van der Meulen MCH. (2006) Effects of surface roughness and maximum load on the mechanical properties of cancellous bone measured by nanoindentation. J Biomed Mater Res 77A: 426-435.
  • Donnelly E and Nelson D. (2002) A study of small crack growth in aluminum alloy 7075-T6 Int J Fatigue 24: 1175-1189.
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Contact Information

Caspary Research Building
6th Floor
541 East 71th St.
New York, NY 10021

Tel  212.774.7214
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