Jane E. Salmon, MD

Dr. Jane Salmon is Professor of Medicine and Professor of Obstetrics and Gynecology at Weill Cornell Medical College and the Collette Kean Research Professor at Hospital for Special Surgery.

Dr. Salmon graduated magna cum laude from New York University and earned a medical degree in 1978 from the College of Physicians and Surgeons of Columbia University, where she was the first woman enrolled in their Medical Scientist Training Program. She completed training in internal medicine at The New York Hospital and in rheumatology at Hospital for Special Surgery, and has been an HSS faculty member since 1983. Dr. Salmon has served on the Board of Directors of the American College of Rheumatology and on the NIH Advisory Boards for the North American Rheumatoid Arthritis Consortium and the Lupus Multiplex Registry. Dr. Salmon was co-editor of Arthritis and Rheumatism and is currently an Associate Editor of Annals of Rheumatic Diseases. At Hospital for Special Surgery, she is a Director of the Lupus and APS Center of Excellence, co-Director of the Mary Kirkland Center for Lupus Research, and Director of the FOCIS Center of Excellence.

Dr. Salmon’s research has focused on elucidating mechanisms of tissue injury in lupus and other autoimmune diseases. Her basic and clinical studies have expanded our understanding of pregnancy loss and organ damage in SLE and the determinants of disease outcome in lupus patients with nephritis, pregnancy, and cardiovascular disease.

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Appointments

Attending Physician, Hospital for Special Surgery
Collette Kean Research Chair, Hospital for Special Surgery
Director, SLE APS Center of Excellence, Hospital for Special Surgery
Senior Scientist, Hospital for Special Surgery
Co-Director, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery
Director of the Lupus Registry and Repository, Hospital for Special Surgery
Professor of Medicine, Weill Cornell Medical College
Professor of Medicine in Obstetrics and Gynecology, Weill Cornell Medical College
Professor, Graduate Program in Immunology, Weill Cornell Graduate School of Medical Sciences

Specialty

Internal Medicine

Special Expertise

Systemic Lupus Erythematosus
Antiphospholipid Syndrome
Rheumatoid Arthritis

Awards

Nanna Swartz lectureship, Swedish Society of Medicine, 2012
Virginia Kneeland Frantz ’22 Distinguished Women in Medicine Award, Columbia P&S Alumni Association, 2012
"Best Doctors in New York," New York magazine, 2009
American Association of Physicians 2008
Carol Nachman Prize in Rheumatology, 2007
Eric Bywaters Memorial Lecture, Imperial College of London, 2007
Edmund L. Dubois, MD, Memorial Lectureship Award, American College of Rheumatology, 2004

Affiliations

Board of Directors, Rheumatology Research Foundation
Scientific Advisory Board, Alliance for Lupus Research
Council Member, Henry Kunkel Society

Specialized Centers

Education

MD, Columbia University College of Physicians and Surgeons, New York

Residency

The New York Hospital, New York, New York

Fellowship

Hospital for Special Surgery, Fellow in Rheumatic Diseases

Certification

Rheumatology
Internal Medicine

State Licensure

New York

Jane E. Salmon, MD has contributed to the following articles on HSS.edu:

Selected Publications

Issuree PDA, Maretzky T, McIlwain DR, Monette S, Qing X, Lang P, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE*, Blobel CP*. IRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest 123:928-32, ePub Jan 25, 2013 *equal contribution.

Isgro J, Gupta S, Jacek E, Pavri T, Duculan R, Kim M, Kirou K, Salmon JE, Pernis AB.  Enhanced ROCK activation in patients with systemic lupus erythematosus.  Arthritis Rheum 65:1592-602, 2013

Lockshin MD, Kim M, Laskin CA, Guerra M, Branch DW, Merrill J, Petri M, Porter F, Sammaritano L, Stephenson MD, Buyon J, Salmon JE. Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticarrdiolipin antibody in patients with anthiphospholipid antibodies. Arthritis Rheum 64:2311-18, 2012

Lynch AM, Salmon JE. Dysregulated Complement Activation as a Common Pathway of Injury in Preeclampsia and Other Pregnancy Complications. Placenta 31: 562-567, 2010

Roman MJ, Salmon JE. Cardiovascular Manifestations of Rheumatologic Diseases. Circulation 116: 2346-2355, 2007.

Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement Activation Induces Dysregulation of Anglogenic Factors and Causes Fetal Rejection and Growth Restriction. J Exp Med 203: 2165-2175, 2006.

Roman M, Moeller E, Davis A, Paget SA, Crow MK, Lockshin MD, Sammaritano L, Devereux RB, Schwartz JE, Levine DM, Salmon JE. Preclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis: Prevalence and Associated Factors. Ann Intern Med 144: 249-256, 2006.

Girardi G, Redecha PB, Salmon JE. Heparin Prevents Antiphospholipid Antibody-induced Fetal Loss by Inhibiting Complement Activation. Nat Med 10: 1222-6, 2004.

Roman, MJ, Shanker B-A, Davis A, Lockshin MD, Sammaritano L, Simantov R, Crow MK, Schwartz JE, Paget SA, Devereux RB, Salmon JE. Prevalence and Correlates of Accelerated Atherosclerosis in Systemic Lupus Erythematosus. New Engl J Med 349: 2399-406, 2003.

Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE. Complement C5a Receptors and Neutrophils Mediate Fetal Injury in the Antiphophospholipid Syndrome. J Clin Invest 112: 1644-54, 2003.

For more publications, please see the PubMed listing.

Selected Books/Chapters

Salmon JE and Kimberly RP: Abnormalities in Immune Complex Clearance and Fc Receptor Function. in: Dubois’ Lupus Erythematosus (Eighth edition), edited by DJ Wallace and BH Hahn, Elsevier Saunders, Philadelphia, pp 12-140, 2013.

Java A, Atkinson J, Salmon J. Defective complement inhibitory function predisposes to renal disease. Annu Rev Med 64:307-24, 2013.

Salmon JE: Mechanisms of immune-mediated injury. in: Cecil Textbook of Medicine (24th edition), edited by L Goldman and AI Schafer, Elsevier Saunders, Philadelphia, pp 226-230, 2012.

Lockshin MD, Salmon JE, Erkan D. Pregnancy and Rheumatic Diseases. In: Maternal-Fetal Medicine (6th edition), edited by RK Creasy and R Resnik Elsevier Health Sciences, Philadelphia, pp1079-1087, 2009.

Erkan D, Salmon JE, Lockshin MD. Antiphospholipid Syndrome. In: Kelley’s Textbook of Rheumatology, 8th Edition, edited by Ruddy S, Harris ED, Jr., Sledge C. Elsevier Saunders, Philadelphia, pp1301-1310, 2008.

Salmon JE. Mechanisms of Immune-mediated Injury. In: Cecil Textbook of Medicine (23rd edition), edited by L Goldman and D Ausiello, Saunders, Philadelphia, pp 266-270, 2008.

Salmon JE, Pricop L, D’Agati V: Immunopathology of SLE. In: Rheumatology 4th Edition, edited by MC Hochberg, AJ Silman, JS Smolen, ME Weinblatt, M Weisman. Mosby, London, pp 1217-1235, 2008.

Selected Presentations

Nanna Swartz Lectureship. Swedish Medical Society, 2012
Annual Ogryzlo Research Day Visiting Professor, University of Toronto, Division of Rheumatology, 2012
Soderberg Prize Symposium, Swedish Society of Medicine, Stockholm, 2010
Theodore E. Woodward Award, American Clinical and Climatological Association, 2007
Carol Nachman Prize in Rheumatology, Premier International Award Recognizing Innovative Research in Rheumatology, 2007
Arthur DeGraff Lecture, New York University School of Medicine, 2007
Eric Bywaters Memorial Lecture, Imperial College of London, 2007
Edmund L. Dubois, MD, Memorial Lectureship Award, American College of Rheumatology, 2004

Research Description

Inflammatory Effector Mechanisms Laboratory

The goal of our research is to identify determinants of disease phenotype in systemic lupus erythematosus (SLE) and related diseases, and to thereby identify targets for therapy. Our laboratory approach is to study effector function and mechanisms of tissue injury. In SLE and other autoimmune diseases, autoantibodies and immune complexes trigger inflammation and organ damage through receptors for Ig (FcgR)and complement activation products. Our work focuses on elucidating mechanisms of tissue injury in lupus and other autoimmune diseases. We study the initiators of damage and the downstream effectors to understand the basis of organ damage in SLE and the predictors and determinants of disease outcome in lupus patients with nephritis, pregnancy, and cardiovascular disease. Our current studies include the following projects:

Research Interests

Systemic Lupus Erythematosus
Antiphospholipid Syndrome
Pregnancy in Autoimmune Patients
Cardiovascular Disease in Autoimmune Patients

Clinical Trials

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Dr. Jane Salmon, Rheumatologist, Internist

Contact Information

Office Locations

Hospital for Special Surgery
535 East 70th Street
New York, NY 10021

Tel: 212.606.1422 (Research)
Tel: 212.606.1728 (Clinical)
Fax: 212.606.1012

Mailing Address

Hospital for Special Surgery
535 East 70th Street
New York, New York 10021

Patient Stories:

Dr. Salmon in the News: