Von Willebrand Factor, Red Cell Fragmentation, and Disease Activity in Systemic Lupus Erythematosus

Rodolfo V. Curiel, MD
Medical Faculty Associates, The George Washington University


Rajkumari Bhagati, MD
Medical Faculty Associates, The George Washington University


Lakshmi Basavaraju, MD
Medical Faculty Associates, The George Washington University


Delona Norton, MPH
Medical Faculty Associates, The George Washington University


James Katz, MD
Medical Faculty Associates, The George Washington University


Elizabeth Haile, MS
Medical Faculty Associates, The George Washington University


Arthur Weinstein, MD
Washington Hospital Center


Abstract
This study sought to determine whether the plasma levels of Von Willebrand factor (vWf) and the degree of red blood cell (RBC) fragmentation on peripheral smear correlate with disease activity in systemic lupus erythematosus (SLE). Forty consecutive patients who fulfilled the criteria for SLE were studied prospectively for 1 year. Patients were categorized according to the SLE Disease Activity Index (SLEDAI) as either active (>2) or inactive disease and followed up monthly (active) or quarterly (inactive). At each visit, patients were examined fully and had complete blood count, tests on antibodies to double-stranded DNA, C3, and C4 levels, and urinalysis. Citrated plasma was analyzed for vWf antigen by standard enzyme-linked immunosorbent assay. A Wright’s stained blood smear was obtained and schistocytes were quantitated on blood smear. The number of schistocytes per 500 RBCs was determined and a schistocyte index (SI) was calculated. At baseline, vWf correlated with SLEDAI (r?=?0.64, p?

This Article appears in HSS Journal: Volume 4, Number 2.
View the full article at springerlink.com.

About the HSS Journal
HSS Journal, an academic peer-reviewed journal, is published twice a year, February and September, and features articles by internal faculty and HSS alumni that present current research and clinical work in the field of musculoskeletal medicine performed at HSS, including research articles, surgical procedures, and case reports.


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