Clinical Trials / Research Studies Directory

Enrolling Clinical Trials and Research Studies

Trial/Study
Principal Investigator
IRB #
A 48-Week, Phase 2b/3a, Double-Blind, Randomized, Placebo Controlled, Multi-center, Superiority Study to Evaluate the Efficacy and Safety of JointStem, Autologous Adipose Tissue Derived Mesenchymal Stem Cells in patients diagnosed with Knee Osteoarthritis
Sabrina M. Strickland, MD
2021-0514
A 52 Week, Randomized, Double Blind Double-Dummy, Parallel-Group, Multi-Center, Non-Inferiority Study to Investigate the Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults with Relapsing or Refractory Eosinophilic Granulomatosis  with Polyangiitus (EGPA) Receiving Standard of Care (Soc) Therapy
Lindsay S. Lally, MD
2022-1010
A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™ (belimumab)
Doruk Erkan, MD, MPH
2015-090
A Double Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of PRA023 in Subjects with Systemic Sclerosis Associated with Interstitial Lung Disease (Ssc-ILD)
Jessica K. Gordon, MD
2022-0436
A Novel Phase 2 Double-Blind, Randomized, Controlled Clinical Trial to Evaluate the Efficacy of Centrally Acting, Non-Toxic ACE Inhibition in Cognitive Impairment Associated with SLE
Kyriakos A. Kirou, MD, DSc, FACP
2020-0226
A Phase 3 Randomized. Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants with Active Systemic Lupus Erythematosus (SLE) (POETYK SLE-2)
Kyriakos A. Kirou, MD, DSc, FACP
2023-0229
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Oral Brepocitinib in Adults with Dermatomyositis
David R. Fernandez, MD, PhD
2022-0733
A Phase II/III Randomized, Double-blind, Placebo-controlled, Multicenter Study to Determine the Efficacy and Safety of ABC008 in the Treatment of Subjects with Inclusion Body Myositis
David R. Fernandez, MD, PhD
2023-0068
A Phase III, Randomized, Double-Blind Placebo-Controlled, Non-Inferiority, Multi-Center Study of the Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease (SHIELD)
Caroline H. Siegel, MD, MS
2023-0408
A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study
Alexander P. Hughes, MD
2014-084
A Prospective, Multicenter, Single-Arm, 2-Phase Early Feasibility Study (EFS) of the HYALEX® Cartilage System
Sabrina M. Strickland, MD
2023-1812
A Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Multicenter Phase 3 Trial to Evaluate the Efficacy, Safety and Tolerability of Ianalumab on Top of Standard-of-Care Therapy in Participants with Active Lupus Nephritis (SIRIUS-LN)
Kyriakos A. Kirou, MD, DSc, FACP
2023-2124
A Randomized, Double-Blind, Placebo-Controlled Study of Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Robert F. Spiera, MD
2018-2011
Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)
Robert F. Speira, MD
2015-267
Adolescence Distance Runner 2D Running Kinematics: Normative Data
Peter D. Fabricant, MD, MPH
2019-0677
Analysis of T and B Cell Repertoire Changes and CTLA4 Genetics and Gene Expression to Understand the Mechanisms of Treatment Response to Orencia (Abatacept) in Rheumatoid Arthritis
S. Louis Bridges, Jr. MD, PhD
2021-0142
Anti-Fibrotic and Anti-Inflammatory Impact of Epigallocatechin Gallate in Anterior Cruciate Ligament Rupture
Scott A. Rodeo, MD
2021-1621
APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.
Doruk Erkan, M.D
2014-252
ASA (ReNu) Efficacy" Organogenesis Inc. Study: “A Phase 3 Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Amniotic Suspension Allograft (ASA) in Patients with Osteoarthritis of the Knee”
Andreas H. Gomoll, MD
2020-2278
Assessment of Frailty in Patients with Polymyalgia Rheumatica
Robert F. Spiera
2018-1823
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD
2014-306
Can Body Composition Help us Better Understand Outcomes in People with Lupus?
Lisa A. Mandl, MD, MPH
2017-1061
Characteristics of Resistance Training and Lifestyle in Touring Professional Golfers
Andrew Creighton, DO
2020-0872
Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes
Vivian P. Bykerk, MD
2014-229
Do Abnormal A-waves Predict IVIG Efficacy in Lower Motor Neuron Syndromes? A Double-Blind Crossover Design
Dale J. Lange, MD
2016-420
Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial
Jacques YaDeau, MD, PhD
2017-0655
ELUCIDATE-Epigenetics; Lupus Urine Cells in Decoding APOL1 Transmutation Effect
Ashira D. Blazer, MD, MSCI
2022-0690
Feasibility of Subantimicrobial-dose Doxycycline for Lateral Elbow Tendinopathy
Brett G. Toresdahl, MD
2020-1582
Foot and Ankle Registry
Jonathan T. Deland, MD
2013-038
Fragile Bone Registry
Joseph M. Lane, MD
2015-165
Genetic Mapping Studies of Adolescent Idiopathic Scoliosis
Cathleen L. Raggio, MD
2014-375
HSS Checkpoint Inhibitor-Associated Immune Related Adverse Events Registry
Karmela Kim Chan, MD
2017-1898
Immune System Regulation in Autoimmune and Inflammatory Diseases
Mary K. Crow, MD
2014-221
Is Indirect Decompression Sufficient for the Treatment of Moderate Central Stenosis: A Randomized Controlled Trial
Sravisht Iyer, MD
2019 - 2228
Long-Term Outcomes of Hybrid Glenoid Compared With a Pegged Implant
Lawrence V. Gulotta, MD
2019-1818
Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters
Beth E. Shubin Stein, MD
2013-112
Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension
Jessica Gordon, MD
2014-265
Pediatric and Adolescent Patellofemoral Instability
Beth Shubin Stein, MD
2014-087
Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features
Susan M. Goodman, MD
2014-233
Phase II Trial of Abaloparatide vs. Placebo in Post-Menopausal Women Receiving Initial Spinal Fusion Surgery
Emily M. Stein, MD, MS
2018-0287
PKRG1 in SLE
Timothy B. Niewold, MD, FACR
2022-1251
Predicting TREATment in Inflammatory Arthritis
Theresa Wampler Muskardin, MD
2022-1201
Preoperative Mindfulness Meditation for Total Knee Arthroplasty: A Pilot Study
Christopher J. Li, MD
2023-2131
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
2014-309
Prospective Randomized Trial of Zynrelef on Postoperative Pain and Opioid Utilization after Total Knee Arthroplasty
Brian P. Chalmers, M.D.
2022-2542
Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF)  for the Treatment of Symptomatic Cervical Radiculopathy
Andrew A. Sama, MD
2014-104
Radiographic Evaluation of Implant Migration for Total Knee Patients
Fernando J. Quevedo González, PhD
2023-2308
Risk Factors for Acute and Overuse Injuries in Adolescent Athletes: A Question-Driven Registry
Peter D. Fabricant, MD, MPH
2021-0487
Scleroderma Cyclophosphamide or Transplantation (SCOT) Study
Robert F. Spiera, MD
26002
Scleroderma Patient Centered Intervention Network (SPIN)
Robert F. Spiera, MD
2014-326
Scleroderma Registry and Repository (Old IRB #26069)
Robert F. Spiera, MD
2014-276
SLE - AWARE: SLE - A Window into APOL1 Regulation and Expression
Ashira D. Blazer, MD, MSCI
2022-0639
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
2014-312
Studies of Immune Deregulation in Patients with SLE
Alessandra Pernis, MD
2014-299
Systemic Lupus Erythematosus (SLE) Treatment with N-acetylcysteine (NAC) (SNAC)
Kyriakos A. Kirou, MD, DSc, FACP
2021-1594
The Center for Hip Preservation Outcomes Registry
Bryan T. Kelly, MD
2014-044
The Effect of Varying Ball Weights on Pitching Kinetics and Kinematics in Youth Baseball Players
Andreas Kontaxis, PhD
2023-0988
The Established Rheumatoid Arthritis Cohort
Susan M. Goodman, MD
2014-234
The IMPACT Study: IMProve Pregnancy in APS with Certolizumab Therapy
Jane E. Salmon, MD
2017-0317
The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry
Cathleen Raggio, MD
2014-166
The Myositis Registry and Repository - 2016
David Fernandez, MD
2014-263
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
The Women’s Soccer and Basketball Health Study: From Head to Toe
Ellen Casey, MD, FASCM
2020-1747
Treatment of plantar fasciitis with radial shockwave therapy vs. focused shockwave therapy: a randomized controlled trial
Kristina Quirolgico, M.D.
2019-1517
Undifferentiated Connective Tissue Disease (UCTD) and Overlap Registry
Lisa R. Sammaritano, MD
2014-311
VCRC Genetic Repository One Time DNA Protocol - 2013
Robert F. Spiera, MD
2014-278
VCRC Genetic Repository One Time DNA Protocol - 2016
Robert F. Spiera, MD
2014-278
Youth Basketball Coach Injury Prevention Survey
Joseph Janosky, Dr.PH, MSc, PT, ATC
2023-0543

Trials and Studies Not Enrolling

Trial/Study
Principal Investigator
IRB #
Not enrolling new patients: (Synovial Tissues) Rheumatoid Arthritis (RA) & Early Rheumatoid Arthritis (ERA) tissue study – Recruitment of patients undergoing synovectomy or upper extremity surgery (UES) or synovial biopsies.
Vivian P. Bykerk, BSc, MD, FRCPC
2014-317
Not enrolling new patients: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants with Moderately To Severely Active Systemic Lupus Erythematosus
Kyriakos A. Kirou, MD, DSc, FACP
2020-1776
Not enrolling new patients: A Multicentre, Randomized, Double-blind, Placebo-Controlled Phase 3 Extension Study to Characterize the Long-term Safety and Tolerability of Anifrolumab in Adult Subjects with Active Systemic Lupus Erythematosus
Kyriakos A. Kirou, MD
2018-0567
Not enrolling new patients: A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE) With Inadequate Response to Standard of Care (SOC) Therapy
Kyriakos A. Kirou, MD, DSc, FACP
2020-0197
Not enrolling new patients: A Pilot Study to Evaluate the Safety and Efficacy of Amniotic Membrane Transplantation in Patients with Arthrofibrosis following Total Knee Arthroplasty
David J. Mayman, MD
2015-069
Not enrolling new patients: A Prospective Study of the Restoration Anatomic Dual Mobility (ADM) X3 Acetabular System
Geoffrey H. Westrich, MD
2015-100
Not enrolling new patients: A Randomized, Double-Blind Controlled, Multicenter Study in SLE Patients Given AKBM-3031or Placebo For 24 Weeks (Randomized Period) and Followed by an Open Label Extension (OLE) Treatment with AKBM-3031 for the Next 24 Weeks
Kyriakos A. Kirou, MD
2018-1099
Not enrolling new patients: A Study of Hyaluronan (Synvisc) for the Treatment of Osteoarthritis in the Thumb: Randomized Control Trial
Lisa A. Mandl, MD, MPH
2014-236
Not enrolling new patients: A Study of Novel Immune Modulating Biomarkers in Patients with Spondyloarthritis with Axial Involvement
Vivian P. Bykerk, MD
2014-227
Not enrolling new patients: An International, Open Label, Randomized Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis
Robert F. Spiera, MD
2014-284
Not enrolling new patients: An Open Label Multicenter Study to Assess the Relationship Between Data Obtained with the LuGENE Multiparameter Transcriptomics Blood Test and Clinical and Standard Laboratory Features of Patients with Systemic Lupus Erythematosus (SLE)
Kyriakos A. Kirou, MD, DSc, FACP
2023-1526
Not enrolling new patients: Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial
Lisa A. Mandl, MD, MPH
2014-243
Not enrolling new patients: Barriers to Recovery in Post Concussive Syndrome
Teena Shetty, MD
2015-809
Not enrolling new patients: Belimumab for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Robert F. Spiera, MD
2014-279
Not enrolling new patients: Biomarkers in Spondyloarthropathies: A Case Control Study
Lisa A. Mandl MD, MPH
2014-240
Not enrolling new patients: Does Chewing Gum Hasten Return of Bowel Function Post-operatively In Patients Following Spinal Surgery? A Prospective, Randomized Controlled  Trial
Russel C. Huang, MD
2014-065
Not enrolling new patients: Evaluation of Intra-articular Injuries as Predictors of Function and Arthritis
Robert G. Marx, MD
23108
Not enrolling new patients: Genetics InFormatics Trial (GIFT) of Warfarin to Prevent DVT
Anne R. Bass, MD
2014-225
Not enrolling new patients: Gleevec in the Treatment of Systemic Sclerosis
Robert F. Spiera, MD
27049
Not enrolling new patients: Gleevec in the Treatment of Systemic Sclerosis - EXTENSION STUDY
Robert F. Spiera, MD
2014-280
Not enrolling new patients: Integrating PROMIS in SLE Clinical Care- Part 2
Lisa A. Mandl, MD, MPH
2018-2264
Not enrolling new patients: Intra-articular Autologous Bone Marrow Aspirate Injection for the Treatment of Knee Osteoarthritis: a Pilot Study with Radiological Follow-up
Gregory E. Lutz, MD
2016-0435
Not enrolling new patients: Longitudinal Evaluation of Hip Cartilage Degeneration: the effect of Femoroacetabular Impingement
Stephen Lyman, PhD
2016-168
Not enrolling new patients: Lower Limb Geometry in Individuals with Atypical Femoral Fractures
Joseph M. Lane, MD
2015-163
Not enrolling new patients: Motion and Muscle Analysis in Individuals with Femoroacetabular Impingement: A Pilot Study
Bryan T. Kelly, MD
2014-030
Not enrolling new patients: Nilotinib in the Treatment of Systemic Sclerosis
Robert F. Spiera, MD
2014-268
Not enrolling new patients: Predicting Clinical and Patient-Centered Outcomes after Surgery for Degenerative Spondylolisthesis
Carol A. Mancuso, MD
2015-237
Not enrolling new patients: Pre-operative Identifiers Indicating Surgical Intervention for Wrist Deformity in Cerebral Palsy
Michelle G. Carlson, MD
26095
Not enrolling new patients: Randomized Control Trial of Essential Amino Acid Supplementation in Protein Deficient Patients Following Total Knee Arthroplasty
David J. Mayman, MD
2015-067
Not enrolling new patients: The Efficacy of Ultrasound Guided Glenohumeral Joint Injections of Platelet Rich Plasma (PRP) versus Hyaluronic Acid (HA) in the Treatment of Glenohumeral Osteoarthritis: A Randomized, Double-blind Control Trial (Old IRB #14134)
Jonathan S. Kirschner, MD, RMSK
2015-188
Not enrolling new patients: The Efficacy of Ultrasound-guided Percutaneous Needle Tenotomy (PNT) versus Platelet Rich Plasma (PRP) with PNT in the Treatment of Chronic Tendinosis
Jonathan S. Kirschner, MD
14135
Not enrolling new patients: The Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension: a Multicenter Study Performed by from the Scleroderma Clinical Trials Consortium (PHAROS)
Jessica K. Gordon, MD
2014-265