Clinical Trials by Condition

Please find clinical trials at HSS listed by the following conditions:

APS (Antiphospholipid Syndrome) Arthritis Arthroplasty (Joint Replacement) Foot and Ankle Conditions Knee Conditions (including ACL) Lupus

Neurological Disorders Shoulder Conditions Spine Conditions Skeletal Dysplasias  Scleroderma Osteoporosis

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery. Learn more

APS (Antiphospholipid Syndrome)

IRB#	Clinical Trial	Principal Investigator
10130	Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without Systemic Lupus Erythematosus	Doruk Erkan, MD
28005	Effects of Fluvastatin on Proinflammatory and Prothrombotic markers in Antiphospholipid Syndrome	Doruk Erkan, MD
28023	Cognitive Dysfunction, Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging (MRI) in Antiphospholipid Antibody (aPL)-negative Systemic Lupus Erythematosus (SLE) versus aPL-positive non-SLE Patients	Doruk Erkan, MD
27022	RITAPS: A Pilot Study Of Rituximab For The Anticoagulation-Resistant Manifestations Of Antiphospholipid Syndrome (APS)	Doruk Erkan, MD
22122	PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)	Jane E. Salmon, MD
95004	Autoimmune Disease Registry and Repository	Jane E. Salmon, MD

Arthritis

IRB#	Clinical Trial	Principal Investigator
26043	A Study of Hyaluronan (Synvisc) for the Treatment of Osteoarthritis in the Thumb: Randomized Control Trial	Lisa A. Mandl, MD, MPH
25022	Quantitative Assessment of the Synovial Vascularity in Early Inflammatory Arthritis	Lisa A. Mandl, MD, MPH
11096	Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry38880	Thomas J.A. Lehman, MD
23034	Open Label Trial for Treating Carpometacarpal Osteoarthritis: PILOT STUDY - Sub-study on Normal Controls	Lisa A. Mandl, MD, MPH
23108	Evaluation of Intra-articular Injuries as Predictors of Function and Arthritis	Robert G. Marx, MD
24067	Database of the Gosden Robinson Early Arthritis Center (EAC): Analysis of Types of Patients Recruited to an Urban EAC	Lisa C. Vasanth, MD
22007	Hyalgan Treatment of Osteoarthritis in Post-Operative Knee Arthroplasty Patients	Geoffrey Westrich, MD
26035	Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial	Lisa A. Mandl, MD, MPH

Arthroplasty

IRB#	Clinical Trial	Principal Investigator
26117	HSS Shoulder Joint Replacement Registry	Robert Marx MD, MSc
27027	Vitamin D Status Among Trauma Patients; Acute Fractures/Non-unions vs. Primary Joint Arthroplasty (control population)	Joseph M. Lane, MD
26073	Evaluation of migration of a cementless, flat, tapered femoral component using RSA	Edwin P. Su, MD
22007	Hyalgan Treatment of Osteoarthritis in Post-Operative Knee Arthroplasty Patients	Geoffrey Westrich, MD
28041	The Effect of Ischemic Preconditioning on Systemic Inflammatory Markers after Total Knee Arthroplasty	Stavros G. Memtsoudis, MD
26115	Minimally Invasive Surgical Approach versus Standard Total Knee Arthroplasty: A Prospective Randomized Double Blinded Study Comparing Postoperative Strength	Bryan J. Nestor. MD
26079	Deep Vein Thrombosis (DVT) Prevention in Total Hip Replacement: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH)	Douglas E. Padgett, MD
21072	The Genetic Factor: Identifying Patients at High Risk for Developing Pulmonary Embolism (PE) After Orthopedic Surgery (Upper Extremity, Spine, THR, TKR) Using A Molecular Screening Test	Geoffrey H. Westrich, MD

Foot and Ankle Conditions

   Ankle Conditions

IRB#	Clinical Trial	Principal Investigator
11066	Randomized Controlled Trial of Platelet-Rich Plasma Versus Whole Blood in the Treatment of Chronic Mid-Portion Achilles Tendinosis	John G. Kennedy, MD
11040	A Prospective, Randomized, Controlled, Multi-Center, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of Augment™ Injectable Bone Graft Compared to Autologous Bone Graft as a Bone Regeneration Device in Hindfoot Fusions	Andrew J. Elliott, MD
28086	Does Pregabalin Reduce Pain after Ankle Surgery?	Jacques T YaDeau, MD, PhD
10105	Duration of Analgesia after Popliteal Fossa Nerve Blockade: Effects of Dexamethasone and Buprenorphine	Jacques T, Ya Deau, MD, PhD

   Foot Conditions

IRB#	Clinical Trial	Principal Investigator
11066	Randomized Controlled Trial of Platelet-Rich Plasma Versus Whole Blood in the Treatment of Chronic Mid-Portion Achilles Tendinosis	John G. Kennedy, MD
11040	A Prospective, Randomized, Controlled, Multi-Center, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of Augment™ Injectable Bone Graft Compared to Autologous Bone Graft as a Bone Regeneration Device in Hindfoot Fusions	Andrew J. Elliott, MD
10105	Duration of Analgesia after Popliteal Fossa Nerve Blockade: Effects of Dexamethasone and Buprenorphine	Jacques T, Ya Deau, MD, PhD
28019	Early Mobilization following Adult Acquired Flatfoot Deformity Reconstruction	Jonathan T. Deland, M.D.
10002	Analgesia after Total Knee Arthroplasty: Peri-Articular Injection vs. Epidural + Femoral Nerve Blockade	Jacques T. YaDeau, MD, PhD
10023	Pharmacodynamics of Ultrasound Guided Popliteal Catheter Infusion after Foot and Ankle Surgery	Daniel B. Maalouf, MD, MPH
10015	Understanding the Effects of the “Ankle Sprain Reducing Shoe” on Ankle Joint Kinetics, Kinematics, Electromyography, and Neuromuscular Balance Control: A Pilot Study	Allison M. Brown, PT, MA
28021	In Vivo Radiographic Validation of Novel EMED Plantar Pressure Masking Algorithm	Jonathan T. Deland, MD
26071	Development of a Geometric Foot Model: A Tool for Clinical Decision Making	Howard J. Hillstrom, PhD

Knee Conditions

IRB#	Clinical Trial	Principal Investigator
11174	The Effect of Postoperative Blood Transfusions on Muscle Tissue Oxygenation after Hip and Knee Arthroplasty.	Stavros G. Memtsoudis, MD, PhD
28008	Lower Extremity Realignment Therapy for the Treatment of Medial Knee Osteoarthritis- A Pilot Study	Howard J. Hillstrom, PhD
11079	Catheter Lateralization by Electrical Stimulation during Epidural Anesthesia	Nigel E. Sharrock, MD
27127	Prospective Study of the effects of Femoral Nerve Block on Quadriceps Strength Post ACL Allograft Reconstruction	Thomas L. Wickiewicz, MD
22129	Bone Tunnel Widening Following ACL (Anterior Cruciate Ligament) Reconstruction	Scott Rodeo, MD
26035	Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial	Lisa A. Mandl, MD, MPH
11043	Effects of Pregabalin on Pain after Total Knee Arthroplasty: A Dose-Response Study	Jacques T. YaDeau, MD, PhD
28041	The Effect of Ischemic Preconditioning on Systemic Inflammatory Markers after Total Knee Arthroplasty	Stavros G. Memtsoudis, MD
10146	Saphenous (Adductor Canal) Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty: A Novel Approach for Postoperative Analgesia	David H. Kim, MD
10122	Revision Anterior Cruciate Ligament Reconstruction in Adolescents	Frank A. Cordasco, MD
26115	Minimally Invasive Surgical Approach versus Standard Total Knee Arthroplasty: A Prospective Randomized Double Blinded Study Comparing Postoperative Strength	Bryan J. Nestor. MD
27142	A Randomized Comparison of NeoCart® to Microfracture for the Repair of Articular Cartilage Injuries in the Knee	Riley J. Williams III, MD

Lupus

IRB#	Clinical Trial	Principal Investigator
11113	A Phase 2B, Dose Ranging Study to Evaluate the Efficacy and Safety of Sifalimumab in Adults with SLE	Kyriakos A. Kirou, MD, DSc, FACP
10117	A Phase 1 Double Blind, Randomized, Single Ascending Dose Study of the Safety and Tolerability of MEDI 570 in SLE	Kyriakos A. Kirou, MD
10130	Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without Systemic Lupus Erythematosus	Doruk Erkan, MD
11141	A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Subcutaneous LY2127399 in Patients with Systemic Lupus Erythematosus (SLE) (ILLUMINATE-2)	Doruk Erkan, M.D.
22122	PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)	Jane E. Salmon, MD
29099	A Phase II Randomized Double- Blind, Placebo- Controlled Study to Evaluate the Efficacy and Safety of Rontalizumab (rhuMAb IFNalpha) In Patients with Moderately to Severely Active SLE.	Kyriakos A. Kirou, MD
93029	Fc Receptor Function in Normals and Systemic Lupus Erythematosus (SLE)	Jane E. Salmon, MD
95004	Autoimmune Disease Registry and Repository	Jane E. Salmon, MD

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Neurological Disorders

   ALS (Amyotrophic Lateral Sclerosis)

IRB#	Clinical Trial	Principal Investigator
29093	Clinical Trial of Ceftriaxone in Subjects with Amyotrophic Lateral Sclerosis	Dale J. Lange, M.D.
29094	Safety and Tolerability of the Ketogenic Diet in ALS	Dale J. Lange, MD
10062	Safety and Efficacy of SOD1 Inhibition by Pyrimethadine in Sporadic ALS	Dale J. Lange, MD
29084	Safety and Efficacy of SOD1 Inhibition by Pyrimethadine in Familial ALS	Dale J. Lange, MD

Shoulder Conditions

IRB#	Clinical Trial	Principal Investigator
27122	Supraclavicular vs Interscalene Brachial Plexus Block for Shoulder Surgery	Christopher A DiMeo, MD
27020	Intraarticular Corticosteroid Injection for Idiopathic Adhesive Capsulitis of the Shoulder	Jennifer L. Solomon, MD
27071	Adhesive Capsulitis: A Quantitative Analysis of Myofibroblast Proliferation	Jo A Hannafin, MD
27050	The Effect of McConnell Shoulder Taping on EMG Activity and Torque Production of the Shoulder Muscles in Subjects With Anterior Shoulder Instability	Sherry I. Backus PT, DPT, MA
11035	Rotator Cuff Repair: A Prospective Randomized Trial Evaluating Two Commonly Performed Techniques	Frank A. Cordasco, M.D.

Spine Conditions

IRB#	Clinical Trial	Principal Investigator
26118	Genetic Mapping Studies of Adolescent Idiopathic Scoliosis	Cathleen L. Raggio, MD
27016	Osteogenic Differentiation of Human Mesenchymal Stem Cells	Wei Zhu, Ph.D.
26033	Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures	Joseph M. Lane, MD

Skeletal Dysplasias

IRB#	Clinical Trial	Principal Investigator
23125	The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry	Cathleen Raggio, MD
25039	A Randomized Double Blind Placebo Controlled Multi-Center Parallel Group Study of One Year Duration Followed by Two Years of open-label Treatment to Determine the Safety and Efficacy of Orally Administered 2.5 mg or 5.0 mg Daily Risedronate	Cathleen L. Raggio, MD

Scleroderma

IRB#	Clinical Trial	Principal Investigator
10041	Nilotinib in the Treatment of Systemic Sclerosis	Robert F. Spiera, MD
10115	The Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension	Jessica K. Gordon, MD
27049	Gleevec in the Treatment of Systemic Sclerosis	Robert F. Spiera, MD
26069	Scleroderma Registry	Robert Spiera, MD
10168	DISTOL 1: Digital Ischemic Lesions in Scleroderma Treated with Oral Treprostinil Diethanolamine: a Randomized, Double-blind, Placebo-controlled, Multicenter Study	Robert F. Spiera, MD

Osteoporosis

IRB#	Clinical Trial	Principal Investigator
27041	Fragile Bone Registry	Joseph M. Lane, MD
26033	Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures	Joseph M. Lane, MD
23017	CORRONA Data Collection Program	Allan Gibofsky, MD
10001	A Randomized, Controlled, Double-Blind Study of the Early Effects of Teriparatide versus Placebo on the Proximal Femur	Mathias P. G. Bostrom, M.D.