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Pain Prevention Research Center

Seeking solutions for pain prevention.

The societal impact of chronic pain is significant, and the effects on those who personally experience chronic pain can be devastating. Pain conditions, like low back pain and headache disorders, have been among the leading causes of disability for decades, according to the Global Burden of Disease Study.  The overall annual cost of chronic pain in the US is estimated at $635 billion. 

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50M+
1 in 5 adults in the US (or 50+M people) live with chronic pain that affects their daily life

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$134.5B
Neck and back pain comprised the highest amount of US healthcare costs in 2016

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40%
Missing work due to low back pain accounts for 40% of workplace absences

The Pain Prevention Research Center at HSS is unique in its focus and commitment to studying the prevention of pain and associated deleterious outcomes. As the #1 ranked hospital for Orthopedics by US News and World Report for 14 years in a row, HSS has an unmatched level of expertise in both treating and preventing musculoskeletal pain. In 2023, our surgical teams performed over 41,500 orthopedic procedures and HSS clinicians provided over 500,000 nonsurgical consultations for musculoskeletal conditions. The large volume of patients seen at HSS combined with our long-standing commitment to clinical and basic science research aligns perfectly with the mission of the Pain Prevention Research Center to seek solutions for pain prevention.

Reframing Pain Treatment

There are limited safe and effective treatments for chronic pain. Most existing treatments are ineffective or only modestly effective for many people. Efforts to develop novel pain treatments have been largely unsuccessful. Given the high prevalence and complexity of chronic pain, as well as its significant personal and societal cost, a pivot in our approach to mitigating pain is critical. The most promising approach may be in its prevention.

We can define pain prevention as three different types: primary prevention, secondary prevention, or tertiary prevention. In the context of pain prevention research, we can define primary prevention as preventing a painful stimulus or preventing a pain condition before it develops, secondary prevention as identifying and treating pain early following a painful stimulus, and tertiary prevention as preventing the persistence or exacerbation of pain. 

Primary Prevention

  • Prevent need for surgery (e.g., spine surgery for those unlikely to benefit)
  • Prevent pain condition (e.g., CRPS)

Secondary Prevention

  • Prevent acute postoperative pain, opioid use & functional impairment

Tertiary Prevention

  • Prevent persistence of postoperative pain, opioid use & functional impairment
  • Prevent persistence or exacerbation of chronic pain

Goals of the Center

The overarching goal of the PPRC is to build a collaborative, dynamic, accessible and inclusive research environment that spans acute and chronic pain, provides supportive and unique training opportunities, and produces clinically meaningful and informative findings that improve patient outcomes. 

To that end, the specific goals of the center are to:

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Identify and evaluate existing approaches and develop novel evidence-based approaches for the design, analysis, and interpretation of clinical trials of the prevention of acute and chronic pain
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Conduct prospective observational and qualitative studies to identify risk factors and to inform timing and potential targets for intervention
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Conduct and disseminate high-quality clinical trials to test the efficacy of innovative interventions to prevent acute and chronic pain and their adverse consequences
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Leverage real-world data, plus computational and statistical approaches to generate real-world evidence of the effectiveness of pain prevention interventions
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Provide multidisciplinary pain research training and mentorship for trainees and early career investigators.

NIH-funded Translational Pain Research Training Program (Pain-Train)

Learn more about Pain-Train, a multidisciplinary, translational pain research curriculum to support trainees in orthopedics and engineering to incorporate pain research methodology into their research.

PPRC staff

 

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HSS Opioid Stewardship for Clinicians

At HSS, our surgeons, anesthesiologists, rheumatologists, physician assistants, nurse practitioners, pharmacists, and social workers have established a framework for assessing and treating opioid-naïve or -dependent patients, using prescription drug monitoring programs, and educating prescribers and patients on multimodal pain management.

Access resources for clinicians including CME credits, research and publications.

 

Other Research Initiatives

Our research into regional anesthesia for total joint replacement surgeries in the Department of Anesthesiology, Critical Care & Pain Management has contributed to an overall increase in regional anesthesia use throughout HSS.

Learn more about our achievements, researchers and publications.

Anesthesia Research Staff