Our multidisciplinary team
approach is essential
to obtaining optimal
outcomes for patients.
- Susan Goodman, MD
IROC Slider
Integrative Rheumatology and Orthopedics Center (IROC)
HSS is focused on clinical care and research in musculoskeletal diseases and serves large patient populations through close collaboration among rheumatologists and orthopedists. For patients with rheumatic diseases like inflammatory arthritis, recommendations for orthopedic surgery must be carefully considered and planned.
The Integrative Rheumatology and Orthopedics Center (IROC) seeks to improve the lives of patients with rheumatic diseases undergoing orthopedic surgery through:
- Patient-centric research in medical and surgical care
- New scientific knowledge to optimize timely patient access and appropriate selection
- Safer and more efficient protocols to achieve optimal clinical outcome
The IROC has the potential to understand the circumstances that predict beneficial outcomes of orthopedic surgery procedures, as well as identify factors that may influence poor outcomes and adverse events. These finding can then be applied more broadly to patients with rheumatic diseases that are undergoing orthopedic surgical procedures. Our multidisciplinary approach including rheumatologists, orthopedists, and basic scientists is essential to defining medical, surgical, and biologic characteristics that contribute to optimal outcomes.
The greatest innovation of the Center will derive from the cross-fertilization of ideas leading to novel projects that occurs when orthopedists, rheumatologists, and basic scientists collaborate on clinical questions. The Center will create and support the intellectual environment that leads to innovative projects through ongoing dialogue and discussion.
Physicians
Scientists
Research Studies
The close working relationship between orthopedists and rheumatologists at HSS has facilitated the development of unique clinical and translational research opportunities. By establishing this research center our goals are to:
- Implement research studies with the goal of increasing access of appropriate patients to orthopedic surgical procedures
- Achieve excellent surgical outcomes while avoiding medical complications, even in those patients with complex rheumatologic diseases
- Ensure that patients achieve their individual goals and optimal satisfaction.
These multidisciplinary efforts will also facilitate translational research that might inform new understanding of disease mechanisms.
Current Research Projects
- The Established Rheumatoid Arthritis Cohort
- Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features
- The PROMIS Rheumatoid Arthritis Longitudinal and Interview Study
- Do SLE Patients have more Early Adverse Events within 6 Months of THR and TKR?
- A Study of Novel Immune Modulating Biomarkers in Patients with Spondyloarthritis with Axial Involvement
- Biomarkers in Spondyloarthropathies: A Case Control Study
- Do Rheumatoid Arthritis Patients Undergoing TKR And THR Require More Transfusions and Have More Pulmonary Disease than OA Controls?
- The RA Biodam Study: Prospective Validation of Soluble Biomarkers as Predictors of Structural Damage in Rheumatoid Arthritis
Educational Resources
Publications
Goodman SM, Bykerk VP, DiCarlo E, Cummings RW, Donlin LT, Orange DE, Hoang A, Mirza S, McNamara M, Andersen K, Bartlett SJ, Szymonifka J, Figgie MP. Flares in Patients with Rheumatoid Arthritis after Total Hip and Total Knee Arthroplasty: Rates, Characteristics, and Risk Factors. J Rheumatol. 2018 Mar 15. pii: jrheum.170366. doi: 10.3899/jrheum.170366. [Epub ahead of print] PubMed PMID: 29545451.
Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB. Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. Nat Commun. 2018 Feb 23;9(1):789. doi: 10.1038/s41467-018-02892-y. PubMed PMID: 29476097; PubMed Central PMCID: PMC5824882.
Stephenson W, Donlin LT, Butler A, Rozo C, Bracken B, Rashidfarrokhi A, Goodman SM, Ivashkiv LB, Bykerk VP, Orange DE, Darnell RB, Swerdlow HP, Satija R. Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation. Nat Commun. 2018 Feb 23;9(1):791. doi: 10.1038/s41467-017-02659-x. PubMed PMID: 29476078; PubMed Central PMCID: PMC5824814.
Orange DE, Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv LB, Pernis AB, Jiang CS, Frank MO, Darnell RB, Lingampali N, Robinson WH, Gravallese E; Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network, Bykerk VP, Goodman SM, Donlin LT. Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data. Arthritis Rheumatol. 2018 Feb 22. doi: 10.1002/art.40428. [Epub ahead of print] PubMed PMID: 29468833.
Mehta BY, Bass AR, Goto R, Russell LA, Parks ML, Figgie MP, Goodman SM. Disparities in Outcomes for Blacks versus Whites Undergoing Total Hip Arthroplasty: A Systematic Literature Review. J Rheumatol. 2018 Feb 1. pii: jrheum.170855. doi: 10.3899/jrheum.170855. [Epub ahead of print] PubMed PMID: 29419468.
Goodman SM. Do Recent Trends in RA Surgery Reflect Success in Disease Management? J Rheumatol. 2018 Feb;45(2):147-149. doi: 10.3899/jrheum.171056. PubMed PMID: 29419445.
Goodman SM, Mandl LA, Parks ML, Zhang M, McHugh KR, Lee YY, Nguyen JT, Russell LA, Bogardus MH, Figgie MP, Bass AR. Disparities in TKA Outcomes: Census Tract Data Show Interactions Between Race and Poverty. Clin Orthop Relat Res. 2016 Sep;474(9):1986-95. doi: 10.1007/s11999-016-4919-8. Epub 2016 Jun 8. PubMed PMID: 27278675; PubMed Central PMCID: PMC4965380.