Clinical Trials / Research Studies by Topic

 

Please find clinical trials at HSS listed by the following topics or view the full directory.

 

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery.

ALS (Amyotrophic Lateral Sclerosis)

Trial/Study
Principal Investigator
IRB #

APS (Antiphospholipid Syndrome)

Trial/Study
Principal Investigator
IRB #
The IMPACT Study: IMProve Pregnancy in APS with Certolizumab Therapy
Jane E. Salmon, MD
2017-0317
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.
Doruk Erkan, M.D
2014-252
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
2014-309
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD
2014-306

Arthritis

Trial/Study
Principal Investigator
IRB #
A 48-Week, Phase 2b/3a, Double-Blind, Randomized, Placebo Controlled, Multi-center, Superiority Study to Evaluate the Efficacy and Safety of JointStem, Autologous Adipose Tissue Derived Mesenchymal Stem Cells in patients diagnosed with Knee Osteoarthritis
Sabrina M. Strickland, MD
2021-0514
ASA (ReNu) Efficacy" Organogenesis Inc. Study: “A Phase 3 Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Amniotic Suspension Allograft (ASA) in Patients with Osteoarthritis of the Knee”
Andreas H. Gomoll, MD
2020-2278
The Women’s Soccer and Basketball Health Study: From Head to Toe
Ellen Casey, MD, FASCM
2020-1747
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
The Established Rheumatoid Arthritis Cohort
Susan M. Goodman, MD
2014-234

Concussion

Trial/Study
Principal Investigator
IRB #

Foot and Ankle Conditions

Ankle Conditions

Trial/Study
Principal Investigator
IRB #
Foot and Ankle Registry
Jonathan T. Deland, MD
2013-038

Foot Conditions

Trial/Study
Principal Investigator
IRB #
Foot and Ankle Registry
Jonathan T. Deland, MD
2013-038

Hand and Wrist Conditions

Hand Conditions

Trial/Study
Principal Investigator
IRB #

Wrist Conditions

Trial/Study
Principal Investigator
IRB #

Hip and Knee Replacement

Trial/Study
Principal Investigator
IRB #
Effect of Duloxetine on Opioid use after Total Knee Arthroplasty. A Double-blinded Randomized Control Trial
Jacques YaDeau, MD, PhD
2017-0655

Hip Conditions

Trial/Study
Principal Investigator
IRB #
The Center for Hip Preservation Outcomes Registry
Bryan T. Kelly, MD
2014-044

Knee Conditions

Trial/Study
Principal Investigator
IRB #
Mpfl Reconstruction for Recurrent Patellofemoral Instability: Rates of Failure vs. Radiographic Parameters
Beth E. Shubin Stein, MD
2013-112
Pediatric and Adolescent Patellofemoral Instability
Beth Shubin Stein, MD
2014-087

Lupus

Trial/Study
Principal Investigator
IRB #
Immune System Regulation in Autoimmune and Inflammatory Diseases
Mary K. Crow, MD
2014-221
Studies of Immune Deregulation in Patients with SLE
Alessandra Pernis, MD
2014-299
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD
2014-306
Undifferentiated Connective Tissue Disease (UCTD) and Overlap Registry
Lisa R. Sammaritano, MD
2014-311
A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™ (belimumab)
Doruk Erkan, MD, MPH
2015-090
Can Body Composition Help us Better Understand Outcomes in People with Lupus?
Lisa A. Mandl, MD, MPH
2017-1061
A Novel Phase 2 Double-Blind, Randomized, Controlled Clinical Trial to Evaluate the Efficacy of Centrally Acting, Non-Toxic ACE Inhibition in Cognitive Impairment Associated with SLE
Kyriakos A. Kirou, MD, DSc, FACP
2020-0226
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
Systemic Lupus Erythematosus (SLE) Treatment with N-acetylcysteine (NAC) (SNAC)
Kyriakos A. Kirou, MD, DSc, FACP
2021-1594
SLE - AWARE: SLE - A Window into APOL1 Regulation and Expression
Ashira D. Blazer, MD, MSCI
2022-0639
ELUCIDATE-Epigenetics; Lupus Urine Cells in Decoding APOL1 Transmutation Effect
Ashira D. Blazer, MD, MSCI
2022-0690
PKRG1 in SLE
Timothy B. Niewold, MD, FACR
2022-1251
A Phase 3 Randomized. Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants with Active Systemic Lupus Erythematosus (SLE) (POETYK SLE-2)
Kyriakos A. Kirou, MD, DSc, FACP
2023-0229
A Phase III, Randomized, Double-Blind Placebo-Controlled, Non-Inferiority, Multi-Center Study of the Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease (SHIELD)
Caroline H. Siegel, MD, MS
2023-0408
A Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Multicenter Phase 3 Trial to Evaluate the Efficacy, Safety and Tolerability of Ianalumab on Top of Standard-of-Care Therapy in Participants with Active Lupus Nephritis (SIRIUS-LN)
Kyriakos A. Kirou, MD, DSc, FACP
2023-2124

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Myositis

Trial/Study
Principal Investigator
IRB #
A Phase II/III Randomized, Double-blind, Placebo-controlled, Multicenter Study to Determine the Efficacy and Safety of ABC008 in the Treatment of Subjects with Inclusion Body Myositis
David R. Fernandez, MD, PhD
2023-0068
The Myositis Registry and Repository - 2016
David Fernandez, MD
2014-263

Osteoporosis

Trial/Study
Principal Investigator
IRB #
The Women’s Soccer and Basketball Health Study: From Head to Toe
Ellen Casey, MD, FASCM
2020-1747
Fragile Bone Registry
Joseph M. Lane, MD
2015-165

Physiatry

Trial/Study
Principal Investigator
IRB #

Rheumatoid Arthritis

Trial/Study
Principal Investigator
IRB #
Predicting TREATment in Inflammatory Arthritis
Theresa Wampler Muskardin, MD
2022-1201
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
2014-312
The Established Rheumatoid Arthritis Cohort
Susan M. Goodman, MD
2014-234
Perioperative Flare in Rheumatoid Arthritis: Characterization of Clinical and Biologic Features
Susan M. Goodman, MD
2014-233
Consortium of Early Arthritis Cohorts USA (CATCH-US) – A prospective cohort study of adults with new onset inflammatory arthritis symptoms to understand predictors of optimal outcomes
Vivian P. Bykerk, MD
2014-229

Scleroderma

Trial/Study
Principal Investigator
IRB #
Scleroderma Patient Centered Intervention Network (SPIN)
Robert F. Spiera, MD
2014-326
A Double Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of PRA023 in Subjects with Systemic Sclerosis Associated with Interstitial Lung Disease (Ssc-ILD)
Jessica K. Gordon, MD
2022-0436
A Randomized, Double-Blind, Placebo-Controlled Study of Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Robert F. Spiera, MD
2018-2011
The Psychosocial Impact of the COVID-19 Pandemic on the Rheumatology Patient Experience
Jillian Rose, PhD, MPH, LCSW
2020-0956
Scleroderma Cyclophosphamide or Transplantation (SCOT) Study
Robert F. Spiera, MD
26002
Scleroderma Registry and Repository (Old IRB #26069)
Robert F. Spiera, MD
2014-276
VCRC Genetic Repository One Time DNA Protocol - 2016
Robert F. Spiera, MD
2014-278
Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension
Jessica Gordon, MD
2014-265

Shoulder Conditions

Trial/Study
Principal Investigator
IRB #

Skeletal Dysplasias

Trial/Study
Principal Investigator
IRB #
The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry
Cathleen Raggio, MD
2014-166

Spine Conditions

Trial/Study
Principal Investigator
IRB #
Prospective, Concurrently Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Spinal KineticsTM M6-C Artificial Cervical Disc Compared to Anterior Cervical Discectomy and Fusion (ACDF)  for the Treatment of Symptomatic Cervical Radiculopathy
Andrew A. Sama, MD
2014-104
A Prospective Analysis of Connective Tissue Factors and Outcomes in Lumbar Spinal Fusion: A Pilot Study
Alexander P. Hughes, MD
2014-084
Genetic Mapping Studies of Adolescent Idiopathic Scoliosis
Cathleen L. Raggio, MD
2014-375

Vasculitis

Trial/Study
Principal Investigator
IRB #
Abatacept (CTLA4-lg) for the Treatment of Relapsing, Non Severe, Granulomatosis with Polyangiitis (Wegener’s) (ABROGATE)
Robert F. Speira, MD
2015-267
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
2014-312