see also Lupus
Joint pain and swelling, skin rash, fatigue and fever are often the primary manifestations of systemic lupus erythematosus (SLE), but people with this autoimmune condition face a variety of health challenges that affect other organs, including the heart and lungs. Between 30-50% of those diagnosed with SLE develop kidney disease or lupus nephritis.
Symptoms and signs of lupus nephritis can include swelling or puffiness of the feet, legs and eyes; high protein levels in the urine; frothy or frequent urination; blood in the urine; and high blood pressure.