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Laboratory of Molecular Osteoarthritis Research

Our goal is to understand the altered signaling pathways that prompt joint tissue disruption in osteoarthritis (OA).

We are using state-of-the-art approaches to define knee OA patient subtypes, assess how different joint tissues contribute to OA disease, and test non-surgical therapies. Our models span cell-based approaches, in vivo systems, and studies that integrate clinical information with multimodal analyses of clinical samples.

We use this information to:

  • Study OA as a whole joint disorder, with emphasis in understanding pain mechanisms, and the contribution of the infrapatellar fat pad to disease onset and progression.
  • Define patient subtypes aiming to develop predictive platforms to identify good candidates for non-surgical treatments or patients who are at risk of developing poor surgical outcomes.
  • Uncover distinct cellular and molecular signatures associated with structural damage and knee fibrosis and stiffness, and target these signatures to modify disease progression.

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